Ann Louise Nixon Cooper was born on January 9, 1902 in Shelbyville, Bedford County, Tennessee, to James Henry Nixon and Molly George Nixon, in a family of six and one boy. Reared in Nashville, Tennessee by uncles and an aunt, she was educated in the public school system of Nashville.

In 1922, in Nashville, Ann Louise Nixon married Albert Berry Cooper, Jr. (deceased). Establishing residence in Atlanta, this couple was blessed with four children: Gwendolyn Yvonne Cooper Mannings (deceased), Joyce Nixon Cooper Bobo, Albert Berry Cooper III, and Ann Marie Cooper Hooper.

Shortly after arriving in Atlanta, Mrs. Ann Nixon Cooper assumed the role of a devoted wife, mother, social leader and community volunteer. She was active with the Georgia Dental Society Auxiliary for many years, serving as president at one time.

For the past fifty odd years, Mrs. Cooper has served on the Board of Directors of Gate City Nursery Association, serving as president of the board and organizing the auxiliary to the board as well as serving in other capacities.

Mrs. Ann Louise Nixon Cooper served on the steering committee to organize a black girls club, subsequently becoming the second president of the board and organizing an auxiliary, the Girls Club Guild, which is still active. During the seventies, she served as a tutor to non-readers at Ebenezer Baptist Church. She also served on the Friends of the Library Board, serving at one time as vice president of the board. In 1980 she received a Community Service Award from Channel 11 for being one of the organizers of the black Cub Scouts and serving as the first den mother for four years.

A social leader, Mrs. Cooper belonged to and in some cases is still active in various social clubs such as the Pollyanna Bridge Club (active during the 1920s and 1930s), the Atlanta Chapter of the Links, Inc. (charter member) and the Jovial Coterie Bridge Club (charter member). She is a longtime member of First Congregational Church, where she has been an active member and participates in many activities and organizations.

Because of her wealth of knowledge of early events and life in Atlanta, her lucidity, vivid memory and mental acuity, Mrs. Cooper has been called upon on many occasions as a source of oral history. Curator Carol Merritt of the Herndon House has sought her expertise concerning the social life of the 1920s and the 1930s. Mrs. Cooper has willingly allowed her collection of early wardrobe styles to be displayed at the Herndon House. She has also donated photographs to the Apex Museum.

Ann Louis Nixon Cooper became a member of the Utopian Literary Club circa 1948, and has remained an active member since that time, serving as president, treasurer and secretary at one time or another.